Monitor Carefully (two)pentobarbital will reduce the extent or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Strong CYP3A4 inducers may well decrease suvorexant efficacy; if greater suvorexant dose necessary, never exceed 20 mg/day
pentobarbital boosts effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Observe. Coadministration of ifosfamide with CYP2B6 inducers could improve metabolism of ifosfamide to its metabolite. Check for increased effects/toxicities if mixed with CYP2B6 inducers.
Watch Carefully (one)pentobarbital will decrease the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to the reduce in fentanyl plasma concentrations, lack of efficacy or, maybe, advancement of the withdrawal syndrome in a very individual who may have formulated physical dependence to fentanyl. After stopping a CYP3A4 inducer, since the effects of the inducer decline, the fentanyl plasma focus will boost which could raise or extend each the therapeutic and adverse effects.
Caution when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may well maximize and can result in potentially lethal respiratory depression.
pentobarbital will decrease the level or result of etravirine by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.
fentanyl intranasal and pentobarbital each boost sedation. Stay clear of or Use Alternate Drug. Restrict use to individuals for whom choice remedy options are insufficient
pentobarbital will decrease the level or outcome of pimozide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.
lasmiditan, pentobarbital. Either improves effects of another by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, which include Alcoholic beverages have not been evaluated in clinical reports. Lasmiditan may lead to sedation, get more info as well as other cognitive and/or neuropsychiatric adverse reactions.
Contraindicated (1)pentobarbital will minimize the level or outcome of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lessen the level or influence of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Potent or reasonable CYP3A4 inducers might raise level of diazepam elimination; thus, efficacy of diazepam might be lowered.
pentobarbital will lessen the extent or effect of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will minimize the extent or effect of norgestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Reasonable CYP3A4 inducers may well minimize progestin focus; think about use of extra barrier approaches
pentobarbital will decrease the level or influence of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will minimize the extent or impact of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.