Monitor Carefully (two)pentobarbital will reduce the extent or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Strong CYP3A4 inducers may well decrease suvorexant efficacy; if greater suvorexant dose necessary, never exceed 20 mg/daypentobarbital boosts effects of ifosfamide by affecting hep